FBXL21 Back

F-box and leucine-rich repeat protein 21

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NCBI Description of FBXL21

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 6 tandem leucine-rich repeats. The amino acid sequence of this protein is highly similar to that of f-box and leucine-rich repeat protein 3A. Comparisons of this gene to orthologous sequences suggest that it may be a pseudogene, and may no longer express a functional protein. Sequence Note: This RefSeq record retains a mismatch versus the reference genome sequence and available transcript data; translation of the genomic sequence results in a nonsense codon and truncation of the predicted protein. In addition, the transcript represents a splice pattern that uses AT-AG splice sites for the last intron, but it is not known if these splice site are functional in vivo.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


FBXL21 is highly significantly mutated in
FBXL21 is significantly mutated in
FBXL21 is near significance in

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Data details

Mutation list for FBXL21