FBXL19 Back

F-box and leucine-rich repeat protein 19

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NCBI Description of FBXL19
This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein binds to the transmembrane receptor ST2L and regulates its ubiquination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants.

Community Annotation of FBXL19 Add / Edit FBXL19: Annotations

No community annotations yet for FBXL19.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FBXL19 is highly significantly mutated in
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FBXL19 is significantly mutated in
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FBXL19 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FBXL19