FASN Back

fatty acid synthase

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of FASN

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.

Community Annotation of FASN Add / Edit FASN: Annotations

No community annotations yet for FASN.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FASN is highly significantly mutated in
(none)
FASN is significantly mutated in
(none)
FASN is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for FASN