FAM189B Back

family with sequence similarity 189, member B

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NCBI Description of FAM189B
This gene is located near the gene for the lysosomal enzyme glucosylceramidase; a deficiency in this enzyme is associated with Gaucher disease. The encoded protein has been identified as a potential binding partner of a WW domain-containing protein which is involved in apoptosis and tumor suppression. Alternative splicing results in multiple transcript variants.

Community Annotation of FAM189B Add / Edit FAM189B: Annotations

No community annotations yet for FAM189B.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FAM189B is highly significantly mutated in
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FAM189B is significantly mutated in
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FAM189B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FAM189B