FAF1 Back

Fas (TNFRSF6) associated factor 1

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NCBI Description of FAF1
Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain.

Community Annotation of FAF1 Add / Edit FAF1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

FAF1 is highly significantly mutated in
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FAF1 is significantly mutated in
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FAF1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for FAF1