F2RL3 Back

coagulation factor II (thrombin) receptor-like 3

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NCBI Description of F2RL3
Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

F2RL3 is highly significantly mutated in
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F2RL3 is significantly mutated in
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F2RL3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for F2RL3