F2RL2 Back

coagulation factor II (thrombin) receptor-like 2

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NCBI Description of F2RL2

This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


F2RL2 is highly significantly mutated in
F2RL2 is significantly mutated in
F2RL2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for F2RL2