F2RL2 Back

coagulation factor II (thrombin) receptor-like 2

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NCBI Description of F2RL2

This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms.

Community Annotation of F2RL2 Add / Edit F2RL2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

F2RL2 is highly significantly mutated in
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F2RL2 is significantly mutated in
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F2RL2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for F2RL2