F2 Back

coagulation factor II (thrombin)

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NCBI Description of F2

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

F2 is highly significantly mutated in
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F2 is significantly mutated in
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F2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for F2