F11R Back

F11 receptor

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NCBI Description of F11R
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of this gene. The extent of this transcript is supported by transcript alignments.

Community Annotation of F11R Add / Edit F11R: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

F11R is highly significantly mutated in
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F11R is significantly mutated in
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F11R is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for F11R