exosome component 3

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NCBI Description of EXOSC3

This gene encodes a non-catalytic component of the human exosome, a complex with 3'-5' exoribonuclease activity that plays a role in numerous RNA processing and degradation activities. Related pseudogenes of this gene are found on chromosome 19 and 21. Alternatively spliced transcript variants encoding different isoforms have been described.

Community Annotation of EXOSC3 Add / Edit EXOSC3: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


EXOSC3 is highly significantly mutated in
EXOSC3 is significantly mutated in
EXOSC3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for EXOSC3