EXOSC1 Back

exosome component 1

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NCBI Description of EXOSC1
This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46.

Community Annotation of EXOSC1 Add / Edit EXOSC1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EXOSC1 is highly significantly mutated in
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EXOSC1 is significantly mutated in
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EXOSC1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EXOSC1