EVX2 Back

even-skipped homeobox 2

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NCBI Description of EVX2
This gene is located at the 5' end of the HOXD gene cluster on chromosome 2. The encoded protein is a homeobox transcription factor that is related to the protein encoded by the Drosophila even-skipped (eve) gene, a member of the pair-rule class of segmentation genes. A 117 kb microdeletion at the 5' end of the HOXD gene cluster, which includes this gene and the HOXD9-HOXD13 genes, causes synpolydactyly, a dominantly inherited disease resulting in limb malformation. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence because no single transcript was available for the full length of the gene. The genomic coordinates used for the transcript record were based on alignments of partial ESTs, homologous transcripts, and data in PMID:1675198.

Community Annotation of EVX2 Add / Edit EVX2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EVX2 is highly significantly mutated in
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EVX2 is significantly mutated in
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EVX2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EVX2