ETS1 Back

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

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NCBI Description of ETS1
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Community Annotation of ETS1 Add / Edit ETS1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ETS1 is highly significantly mutated in
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ETS1 is significantly mutated in
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ETS1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ETS1