ETF1 Back

eukaryotic translation termination factor 1

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NCBI Description of ETF1
This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in coding and non-coding transcript variants. Pseudogenes of this gene are found on chromosomes 5, 7 and X.

Community Annotation of ETF1 Add / Edit ETF1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ETF1 is highly significantly mutated in
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ETF1 is significantly mutated in
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ETF1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ETF1