ESX1 Back

ESX homeobox 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ESX1
This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis.

Community Annotation of ESX1 Add / Edit ESX1: Annotations

No community annotations yet for ESX1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ESX1 is highly significantly mutated in
(none)
ESX1 is significantly mutated in
(none)
ESX1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ESX1