ESR2 Back

estrogen receptor 2 (ER beta)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ESR2
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.

Community Annotation of ESR2 Add / Edit ESR2: Annotations

No community annotations yet for ESR2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ESR2 is highly significantly mutated in
(none)
ESR2 is significantly mutated in
(none)
ESR2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ESR2