ERN1 Back

endoplasmic reticulum to nucleus signaling 1

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NCBI Description of ERN1
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals.

Community Annotation of ERN1 Add / Edit ERN1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ERN1 is highly significantly mutated in
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ERN1 is significantly mutated in
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ERN1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ERN1