ER lipid raft associated 2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ERLIN2

This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of ERLIN2 Add / Edit ERLIN2: Annotations

No community annotations yet for ERLIN2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ERLIN2 is highly significantly mutated in
ERLIN2 is significantly mutated in
ERLIN2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ERLIN2