ERLEC1 Back

endoplasmic reticulum lectin 1

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NCBI Description of ERLEC1
This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21.

Community Annotation of ERLEC1 Add / Edit ERLEC1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ERLEC1 is highly significantly mutated in
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ERLEC1 is significantly mutated in
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ERLEC1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ERLEC1