endoplasmic reticulum lectin 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ERLEC1

This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21.

Community Annotation of ERLEC1 Add / Edit ERLEC1: Annotations

No community annotations yet for ERLEC1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ERLEC1 is highly significantly mutated in
ERLEC1 is significantly mutated in
ERLEC1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ERLEC1