ERCC4 Back

excision repair cross-complementing rodent repair deficiency, complementation group 4

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NCBI Description of ERCC4
The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).

Community Annotation of ERCC4 Add / Edit ERCC4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ERCC4 is highly significantly mutated in
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ERCC4 is significantly mutated in
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ERCC4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ERCC4