ERCC2 Back

excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)

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NCBI Description of ERCC2

Community Annotation of ERCC2 Add / Edit ERCC2: Annotations

Somatic ERCC2 mutations in urothelial carcinoma have been associated with complete response to platinum-based chemotherapy. This may be a result of loss of function in nucleotide excision repair as a result of this defect.

Added by Eli Van Allen

2

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ERCC2 is highly significantly mutated in
Bladder
BLCA
13 patients (13%)
ERCC2 is significantly mutated in
ERCC2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ERCC2