ERBB2IP Back

erbb2 interacting protein

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NCBI Description of ERBB2IP
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ERBB2IP is highly significantly mutated in
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ERBB2IP is significantly mutated in
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ERBB2IP is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ERBB2IP