ERAP1 Back

endoplasmic reticulum aminopeptidase 1

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NCBI Description of ERAP1

The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.

Community Annotation of ERAP1 Add / Edit ERAP1: Annotations

No community annotations yet for ERAP1.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ERAP1 is highly significantly mutated in
ERAP1 is significantly mutated in
ERAP1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ERAP1