EPS15 Back

epidermal growth factor receptor pathway substrate 15

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NCBI Description of EPS15

This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Community Annotation of EPS15 Add / Edit EPS15: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EPS15 is highly significantly mutated in
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EPS15 is significantly mutated in
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EPS15 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for EPS15