EPO Back

erythropoietin

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NCBI Description of EPO

This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types.

Community Annotation of EPO Add / Edit EPO: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EPO is highly significantly mutated in
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EPO is significantly mutated in
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EPO is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for EPO