EPHX2 Back

epoxide hydrolase 2, cytoplasmic

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NCBI Description of EPHX2
This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EPHX2 is highly significantly mutated in
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EPHX2 is significantly mutated in
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EPHX2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EPHX2