EPHX1 Back

epoxide hydrolase 1, microsomal (xenobiotic)

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NCBI Description of EPHX1
Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EPHX1 is highly significantly mutated in
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EPHX1 is significantly mutated in
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EPHX1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EPHX1