EPCAM Back

epithelial cell adhesion molecule

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NCBI Description of EPCAM
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.

Community Annotation of EPCAM Add / Edit EPCAM: Annotations

No community annotations yet for EPCAM.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EPCAM is highly significantly mutated in
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EPCAM is significantly mutated in
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EPCAM is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EPCAM