endonuclease G

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NCBI Description of ENDOG

The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA.

Community Annotation of ENDOG Add / Edit ENDOG: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ENDOG is highly significantly mutated in
ENDOG is significantly mutated in
ENDOG is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ENDOG