EME1 Back

essential meiotic endonuclease 1 homolog 1 (S. pombe)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of EME1
This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.

Community Annotation of EME1 Add / Edit EME1: Annotations

No community annotations yet for EME1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EME1 is highly significantly mutated in
(none)
EME1 is significantly mutated in
(none)
EME1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EME1