ELAVL1 Back

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)

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NCBI Description of ELAVL1
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.

Community Annotation of ELAVL1 Add / Edit ELAVL1: Annotations

elavl1

Added by Peter King

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ELAVL1 is highly significantly mutated in
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ELAVL1 is significantly mutated in
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ELAVL1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ELAVL1