ELAC2 Back

elaC homolog 2 (E. coli)

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NCBI Description of ELAC2
The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of ELAC2 Add / Edit ELAC2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ELAC2 is highly significantly mutated in
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ELAC2 is significantly mutated in
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ELAC2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ELAC2