EIF4EBP1 Back

eukaryotic translation initiation factor 4E binding protein 1

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NCBI Description of EIF4EBP1
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EIF4EBP1 is highly significantly mutated in
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EIF4EBP1 is significantly mutated in
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EIF4EBP1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EIF4EBP1