EIF2C3 Back

eukaryotic translation initiation factor 2C, 3

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NCBI Description of EIF2C3
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene.

Community Annotation of EIF2C3 Add / Edit EIF2C3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EIF2C3 is highly significantly mutated in
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EIF2C3 is significantly mutated in
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EIF2C3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EIF2C3