EIF2B4 Back

eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa

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NCBI Description of EIF2B4
Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of EIF2B4 Add / Edit EIF2B4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EIF2B4 is highly significantly mutated in
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EIF2B4 is significantly mutated in
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EIF2B4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EIF2B4