EIF2B3 Back

eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa

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NCBI Description of EIF2B3

The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EIF2B3 is highly significantly mutated in
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EIF2B3 is significantly mutated in
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EIF2B3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for EIF2B3