EIF2B1 Back

eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa

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NCBI Description of EIF2B1

This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


EIF2B1 is highly significantly mutated in
EIF2B1 is significantly mutated in
EIF2B1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for EIF2B1