EIF2AK4 Back

eukaryotic translation initiation factor 2 alpha kinase 4

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NCBI Description of EIF2AK4

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999 [PubMed 10504407]).[supplied by OMIM, Mar 2008].

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


EIF2AK4 is highly significantly mutated in
EIF2AK4 is significantly mutated in
EIF2AK4 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for EIF2AK4