EIF2AK3 Back

eukaryotic translation initiation factor 2-alpha kinase 3

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NCBI Description of EIF2AK3
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EIF2AK3 is highly significantly mutated in
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EIF2AK3 is significantly mutated in
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EIF2AK3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EIF2AK3