EIF2AK2 Back

eukaryotic translation initiation factor 2-alpha kinase 2

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NCBI Description of EIF2AK2

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


EIF2AK2 is highly significantly mutated in
EIF2AK2 is significantly mutated in
EIF2AK2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for EIF2AK2