EIF2AK1 Back

eukaryotic translation initiation factor 2-alpha kinase 1

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NCBI Description of EIF2AK1

The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of EIF2AK1 Add / Edit EIF2AK1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


EIF2AK1 is highly significantly mutated in
EIF2AK1 is significantly mutated in
EIF2AK1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for EIF2AK1