EHD1 Back

EH-domain containing 1

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NCBI Description of EHD1
This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors.

Community Annotation of EHD1 Add / Edit EHD1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EHD1 is highly significantly mutated in
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EHD1 is significantly mutated in
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EHD1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EHD1