EFCAB6 Back

EF-hand calcium binding domain 6

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NCBI Description of EFCAB6
This gene encodes a protein which directly binds the oncogene DJ-1 and androgen receptor to form a ternary complex in cells. This binding protein recruits histone-deacetylase complexes in order to repress transcription activity of androgen receptor. This protein may also play a role in spermatogenesis and fertilization. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of EFCAB6 Add / Edit EFCAB6: Annotations

No community annotations yet for EFCAB6.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EFCAB6 is highly significantly mutated in
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EFCAB6 is significantly mutated in
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EFCAB6 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EFCAB6