EED Back

embryonic ectoderm development

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of EED
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene.

Community Annotation of EED Add / Edit EED: Annotations

No community annotations yet for EED.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EED is highly significantly mutated in
(none)
EED is significantly mutated in
(none)
EED is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EED