endothelin receptor type A

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NCBI Description of EDNRA

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.

Community Annotation of EDNRA Add / Edit EDNRA: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


EDNRA is highly significantly mutated in
EDNRA is significantly mutated in
EDNRA is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for EDNRA