EDN2 Back

endothelin 2

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NCBI Description of EDN2
This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EDN2 is highly significantly mutated in
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EDN2 is significantly mutated in
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EDN2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EDN2