EDEM3 Back

ER degradation enhancer, mannosidase alpha-like 3

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NCBI Description of EDEM3
Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008].

Community Annotation of EDEM3 Add / Edit EDEM3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EDEM3 is highly significantly mutated in
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EDEM3 is significantly mutated in
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EDEM3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EDEM3