EDEM2 Back

ER degradation enhancer, mannosidase alpha-like 2

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NCBI Description of EDEM2
In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).[supplied by OMIM, Mar 2008].

Community Annotation of EDEM2 Add / Edit EDEM2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EDEM2 is highly significantly mutated in
(none)
EDEM2 is significantly mutated in
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EDEM2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EDEM2