EBI3 Back

Epstein-Barr virus induced gene 3

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NCBI Description of EBI3
This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

EBI3 is highly significantly mutated in
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EBI3 is significantly mutated in
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EBI3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for EBI3