E2F3 Back

E2F transcription factor 3

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of E2F3
This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants.

Community Annotation of E2F3 Add / Edit E2F3: Annotations

No community annotations yet for E2F3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

E2F3 is highly significantly mutated in
(none)
E2F3 is significantly mutated in
(none)
E2F3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for E2F3