NCBI Description of E2F3
|This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants.|
Community Annotation of E2F3 Add / Edit E2F3: Annotations
No community annotations yet for E2F3.
• "Mouse over" a mutation to see details.
Click on a tumor type to see its full list of significant genes.